Drug Standardization, HPTLC Finger Printing, Toxicity Research Studies of ASU Herbaceous Plant Fruit Seeds Part Samples of Ipomoea nil (Linn.) Roth (2025)

Scientific assessment, research studies of botanical, pharmacognostical, biodiversity and toxicological of ASU herbal drug Kaladana/ Habb-ul-Neel (Ipomoea nil (Linn.) Roth.) seeds

Journal of Pharmacognosy and Phytochemistry, 2024

Abstract Background: Botanical, Pharmacognostical, Biodiversity and Toxicological research studies of ASU herbal single drugs / products remains a big challenging task. There needs to be more than the advance investigation research studies and screening parameters to validation, authenticate, identification and differentiate adulterants in ASU medicinal plants. Ipomoea nil (Linn.) Roth. is one of the herb used to treat various health wellness and therapeutic illness of public mankind.Aims and Objectives: This study aims to evaluate the Botanical, Pharmacognostical, Biodiversity and Toxicological research studies of the seeds part of plant of I N. Materials and Methods: The Botanical, Pharmacognostical, Biodiversity and Toxicological authenticate identification, quality control research studies of the seeds part of plant of I N. powder were carried out using standard methods. The studies explored of quality, safety and toxicity effects of the tested drug samples were also investigated applied standard methods WHO/AOAC/AYUSH pharmacopoeias. Results and Conclusion: The Botanical, Pharmacognostical, Biodiversity, Toxicological QC. QA. Properties of I N. have shown that all the parameters were within the permissible limits. The tested drug samples showed significant quality, safety and toxicity studies against certain pathogens organisms and promising anti-pathogenic activity. In the investigated studies of Botanical, Pharmacognostical, QC. Toxicological research findings revealed that the revalidated test drug was free from adulterations and toxic contamination's. This investigated herb research data confirmed to revalidated of drug standardization and therapeutically may treat that the drug is safe for internal use and cures in Cold, Dropsy, Gout, Joint pain, Vitiligo, Itching, Asthma and Anthelmintic disorder etc. Keywords: I N., Ipomoea nil (Linn.) Roth. botanical Pharmacognostical, biodiversity, QC. and QA, toxicological, and pharmacological quality, safety and toxicity studies

Review Article: Standardization and Evaluation of Herbal Drugs is Need of the Hour in Present Era

2020

The herbal preparations are being into used from the primordial time throughout the world. Now, maximum people are shifted towards the Ayurveda for the treatment of any affliction. Herbs are also used as side products in the preparation of synthetic medicine. Traditional system of medicine has taken over the place worldwide, hence majority of products are formulated. The increased use of herbal drug, now concerning with its purity and quality of herbal raw material as well as finished product. Purity of the herbal constituent is the main problem faced by the herbal industries. To overcome this issue, WHO has published the certain guidelines for the standardization of the herbal material. To ensure the efficacy, purity and quality control processes, the personnel should himself supervise the standardization processes with uniform rules. The review represents the standardization parameters with the standards value of quality, purity and efficacy.

Herbal Medicines: A Potent Approach to Human Diseases, Their Chief Compounds, Formulations, Present Status, and Future Aspects

International Journal of Membrane Science and Technology

Humans have relied on herbal medicines in health care and the treatment of numerous diseases since the very early stages of civilization. Herbal medicines or phytomedicines not only treat sickness but also guard against its complications simultaneously. The continuous use of synthetic medications is not safe for health because of their extreme negative impacts. So now a days, we can estimate that in some developing countries, such as the USA and England, herbal drugs make up to 25% of all consumption; on the other hand, in a few nations that are rapidly developing, like India and China, it comprises up to 80%. All over the world, more than ten thousand medicinal species are present. India is a well known producer of herbal plants that have a history of being used medicinally. As per the data of the International Union for Conservation of Nature (IUCN) and the World Wide Fund for Nature (WWF), there are 50000-80000 types of flowering plants that have medicinal value globally. Because...

Current Status of Herbal Drug Standards in the Indian Pharmacopoeia

Phytotherapy research : PTR, 2017

The benefits of herbal drugs were well understood way back. They have been used for the promotion of health and medical purposes - in disease conditions. It is a conventional belief that herbal drugs have no side effects, are cheaper and locally available. Among Indian systems of medicines, herbs/herbal formulations are used to a larger extent. The quality control of the marketed herbs/herbal formulations is important for acquiring optimum therapeutic benefit as well as for expanding global outreach. Therefore, herbal drug standards are important. Reference standards, the Indian Pharmacopoeia Reference Substances especially the botanical reference substances and the phytochemical reference substances are required for comparison of quality of herbal drugs. The Indian Pharmacopoeia Commission has initiated the process of providing Indian Pharmacopoeia Reference Substances to the stakeholders. Therefore, this article provides an overview of the history and the status of herbal drug sta...

STANDARDIZATION AND EVALUATION OF HERBAL MEDICINES LATEST

Standardization of herbal medicines is the process of prescribing a set of standards or inherent characteristics, constant parameters, definitive qualitative and quantitative values that carry an assurance of quality, efficacy, safety and reproducibility. To do so, there must be clear technical methods by which this these objectives can be achieved. Current review has tried to compile and present available official methods of standardization of herbal medicines in simple and clear way to address such gap.

Standardization, evaluation and quantification of herbal drugs by various analytical methods

International Journal of Ayurvedic Medicine

This review article encompasses the various evaluation parameters of standardization of different medicinal plants and its constituents. In today’s life, more and more people of the world are turning towards the use of natural or herbal products as these have very less or negligible side effects. As the use of herbal medicinal products is increasing day by day, the questions regarding their quality are also arising. This is due to lack of parameters for the standardization of these products. There is a need to set different parameters or methods that can help to standardize the herbal medicinal plant materials. Various methods like physical, chemical, biological is used for standardization and quality evaluation of herbal medicinal plants. These methods can act as a basic tool for the quality evaluation of herbal plant materials. Different parameters of standardization are the fundamental tool for evaluating and assuring the quality of the herbal plant material and its products. Thi...

Analytical Evaluation of Herbal Drugs

Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines (phytotherapeutic agents)

Brazilian Journal of Medical and Biological Research, 2000

This review highlights the current advances in knowledge about the safety, efficacy, quality control, marketing and regulatory aspects of botanical medicines. Phytotherapeutic agents are standardized herbal preparations consisting of complex mixtures of one or more plants which contain as active ingredients plant parts or plant material in the crude or processed state. A marked growth in the worldwide phytotherapeutic market has occurred over the last 15 years. For the European and USA markets alone, this will reach about $7 billion and $5 billion per annum, respectively, in 1999, and has thus attracted the interest of most large pharmaceutical companies. Insufficient data exist for most plants to guarantee their quality, efficacy and safety. The idea that herbal drugs are safe and free from side effects is false. Plants contain hundreds of constituents and some of them are very toxic, such as the most cytotoxic anti-cancer plant-derived drugs, digitalis and the pyrrolizidine alkaloids, etc. However, the adverse effects of phytotherapeutic agents are less frequent compared with synthetic drugs, but well-controlled clinical trials have now confirmed that such effects really exist. Several regulatory models for herbal medicines are currently available including prescription drugs, over-the-counter substances, traditional medicines and dietary supplements. Harmonization and improvement in the processes of regulation is needed, and the general tendency is to perpetuate the German Commission E experience, which combines scientific studies and traditional knowledge (monographs). Finally, the trend in the domestication, production and biotechnological studies and genetic improvement of medicinal plants, instead of the use of plants harvested in the wild, will offer great advantages, since it will be possible to obtain uniform and high quality raw materials which are fundamental to the efficacy and safety of herbal drugs.

Review on Some Selected Herbal Plants for its Traditional and Medicinal Uses - A Novel Approach

International Journal of Pharmaceutical Sciences Review and Research, 2022

Use of herbal products has been increased dramatically for the past few years. The herbal medicine industry is growing at an astounding rate. The knowledge base devoted to the adverse effects of these products has not grown in proportion to their increased usage. Even in some resources misleading information about the beneficial and adverse effects of some herbal plants can be found. Each plant reviews the herbs status including traditional and current uses. Traditional physicians and scientists generally believe that, if a plant has any medicinal value it is because of the presence of the active principle constituents present in that herbal plants that must be isolated, purified and used. The present review is designed to provide the necessary information regarding traditional and medicinal uses of some herbal plants.

Provisional Biopharmaceutical Classification of Some Common Herbs Used in Western Medicine

Molecular Pharmaceutics, 2012

The aim of this study was to classify some markers of common herbs used in Western medicine according to the Biopharmaceutical Classification System (BCS). The BCS is a scientific approach to classify drug substances based upon their intestinal permeability and their solubility, at the highest single dose used, within the physiologically relevant pH ranges. Known marker components of twelve herbs were chosen from the USP Dietary Supplement Compendium Monographs. Different BCS parameters such as intestinal permeability (P eff ) and solubility (C s ) were predicted using the ADMET Predictor, which is a software program to estimate biopharmaceutical relevant molecular descriptors. The dose number (D 0 ) was calculated when information from the literature was available to identify an upper dose for individual markers. In these cases the herbs were classified according to the traditional BCS parameters using P eff and D 0 . When no upper dose could be determined, then the amount of a marker that is just soluble in 250 mL of water was calculated. This value, M x , defines when a marker is changing from highly soluble to poorly soluble according to BCS criteria. This biopharmaceutically relevant value can be a useful tool for marker selection. The present study showed that a provisional BCS classification of herbs is possible but some special considerations need to be included into the classification strategy. The BCS classification can be used to choose appropriate quality control tests for products containing these markers. A provisional BCS classification of twelve common herbs and their 35 marker compounds is presented.